The Oakwood Campus is the original campus of Lanier Technical College and is located near exit 16 of I-985. The campus features seven buildings with lots of parking and green space as well as a large, well-furnished library, two student centers, and a 210-seat lecture hall. Classrooms provide opportunities for small class sizes to enhance the learning process.

The campus opened in January 1967 with a new 47,000 square foot administrative and classroom building. During the mid-1970s, the campus facilities were expanded to include a modern industrial training facility and 20,000 square feet of classroom, laboratory, and administrative space. Additional buildings of 26,000 square feet and 47,000 square feet were added in 1981 and 1996 respectively. In 2002, the 5,000 square foot Ammonia Refrigerant Building was added to the campus.

Located adjacent to Gainesville College and the Lanier Career Center, the campus allows seamless learning opportunities from high school to technical college to a two-year college and beyond. Its location facilitates Oakwood Campus students taking advantage of dual enrollment at the high school and college level thus fulfilling the college's mission of meeting the educational and technological needs of the community.